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Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which results in degradation of cGMP in the corpus cavernosum of the penis. In the absence of sexual stimulation, sildenafil acts like a vacuum and will not cause an erection. The presence of sildenafil, it helps to prevent degradation of PDE5 by cGMP stimulation allowing normal sexual to cause an erection.
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